The Open Systems Interconnection protocols are a family of information exchange standards developed jointly by the ISO and the ITU-T. The standardization process began in 1977.

<networking> (OSI-RM, OSI Reference Model, seven layer model) A model of network architecture and a suite of protocols (a protocol stack) to implement it, developed by ISO in 1978 as a framework for international standards in heterogeneous computer network architecture. The OSI architecture is split between seven layers, from lowest to highest: 1 physical layer, 2 data link layer, 3 network layer, 4 transport layer, 5 session layer, 6 presentation layer, 7 application layer. Each layer uses the layer immediately below it and provides a service to the layer above. In some implementations a layer may itself be composed of sub-layers. OSI is the umbrella name for a series of non-proprietary protocols and specifications, comprising, among others, the OSI Reference Model, ASN.1 (Abstract Syntax Notation 1), BER (Basic Encoding Rules), CMIP and CMIS (Common Management Information Protocol and Services), X.400 (Message Handling System, or MHS), X.500 (Directory Service), Z39.50 (search and retrieval protocol used by WAIS), and many others. Apart from its actual application to real protocols, it also serves as a useful teaching model. (2004-02-13)

OSI-7904 is a noncompetitive liposomal thymidylate synthase inhibitor. OSI-7904 is a benzoquinazoline folate analog with antineoplastic activity.